Background: Sorting Nexin 27 regulates intracellular trafficking of proteins through the endosomal system. Results: An interaction between SNX27 and the guanine nucleotide exchange factor -Pix in complex with Git family proteins is identified. Conclusion: Cells lacking SNX27 have decreased cell motility, which we propose to be due to -Pix intracellular trafficking defects. Significance: The results and model proposed have implications for recruitment/activation of p21-activated kinase (PAK) or Rho GTPases at focal adhesions.
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