(1) TKA implants should well fit on each patient’s anatomy. Statistical Shape Models (SSM) statistically represent the anatomy of a given population. The aims of this study were to assess how to generate a valid SSM for implant design and provide guidelines and examples on how to use the SSMs to evaluate the anatomic fit of TKA components. (2) Methods: A Caucasian SSM was built from 120 anatomies (65 female, 55 male) and an Asian SSM was based on 112 patients (75 female, 37 male). These SSMs were used to generate a database of 20 bone models. The AP/ML dimensions of the bone models were compared to those of the input population. Design input parameters, such as the tibial contour, trochlea, and femur curvature were extracted from the SSMs. Femur and patella components were virtually implanted on the bone models. (3) Results: the dimensions of the generated bone models well represented the population. The overhang of the femoral component as well as the coverage and peak restoration of the patella component were visualized. (4) Conclusions: SSMs can be used to efficiently gain input into TKA design and evaluate the implant fit on the studied population.