Interleukin-(IL-) 12 has been recently suggested to participate during development of insulin resistance in obese mice. Nevertheless, serum IL-12 levels have not been accurately determined in overweight and obese humans. We thus studied serum concentrations of IL-12 in Mexican adult individuals, examining their relationship with low-grade inflammation and obesity-related parameters. A total of 147 healthy individuals, 43 normal weight, 61 overweight, and 43 obese subjects participated in the study. Circulating levels of IL-12, tumor necrosis factor-alpha (TNF-α), leptin, insulin, glucose, total cholesterol, and triglyceride were measured after overnight fasting in all of the study subjects. Waist circumference and body fat percentage were recorded for all the participants. Serum IL-12 was significantly higher in overweight and obese individuals than in normal weight controls. Besides being strongly related with body mass index (r = 0.5154), serum IL-12 exhibited a significant relationship with abdominal obesity (r = 0.4481), body fat percentage (r = 0.5625), serum glucose (r = 0.3158), triglyceride (r = 0.3714), and TNF-α (r = 0.4717). Thus, serum levels of IL-12 are increased in overweight and obese individuals and show a strong relationship with markers of low-grade inflammation and obesity in the Mexican adult population. Further research is needed to understand the role of IL-12 in developing obesity-associated alterations in humans.
mortalidad. Resultados: Se incluyeron 154 casos, 59 mujeres y 95 hombres. El principal órgano causante de sepsis abdominal fue el apéndice (41.6%). La mortalidad global fue del 14.3%. La presencia de fallas orgánicas fue del 35.1%. El valor medio de HDL se situó en 37.64 mg/dl (desviación estándar: ± 16.16). Los hallazgos, sometidos a verificación estadística mediante la prueba t de Student, mostraron significancia entre los casos con SOFA > 4 (p = 0.01) y Mannheim > 26 (p = 0.001), CONUT > 6 (p = 0.001), presencia de fallas orgánicas (p = 0.001) y mortalidad (p = 0.003). Conclusión: Los valores de HDL se relacionan con la gravedad, con el desarrollo de fallas orgánicas y con la mortalidad en la sepsis.
149 patients (23.1%) with AA (65.7% in right colon). The median surveillance interval between colonoscopies was 60.0 months (36.0-60.0 IQR). On surveillance colonoscopy, the odds of having any adenoma in any part of the colon was 0.95 (95%CI 0.68-1.31; pZ0.74) in both groups; while the OR of having any AA was 1.26 (95%C 0.83-1.92; pZ0.29). However, patients with exclusively with right versus left colon adenoma had a significantly higher prevalence of metachronous exclusive right colon adenoma [54.45 vs 41.2%, p<0.001]. Conclusions: Having only right colon adenomas is more prevalent than only left colon adenomas. Patients with only right colon adenomas on index colonoscopy, when compared to those with only left colon adenomas: Don't have a higher risk of metachronous advanced adenomas. Have a higher risk of metachronous right sided only adenomas. This re-emphasizes the importance of a high-quality right colon examination.
En los últimos meses del 2019 apareció el nuevo coronavirus tipo 2, causante del síndrome respiratorio agudo severo (SARS-CoV-2). Las recientes recomendaciones de organismos internacionales y asociaciones endoscópicas permiten al endoscopista crear un ambiente seguro, mediante el uso de equipos de protección personal(EPP). Lo anterior motiva la creación de nuevos dispositivos barrera que agregan capacidad de defensa al endoscopista, siendo el objetivo de nuestro trabajo dar a conocer los diferentes dispositivos de seguridad desarrollados en la práctica de la endoscopia durante la pandemia por enfermedad por coronavirus 2019 (COVID-19), además de mencionar aquellos que se utilizaron en el Servicio de Endoscopia Gastrointestinal del Hospital General de México "Dr. Eduardo Liceaga". Conclusiones: Los dispositivos utilizados representan una herramienta coadyuvante en la reducción de gotas y aerosoles durante la endoscopia gastrointestinal superior. Estos dispositivos no se consideran como un reemplazo para los otros EPP, pero pueden ayudar a prevenir la propagación de la COVID-19 entre el personal médico y el paciente, además de futuras enfermedades respiratorias similares graves durante procedimientos endoscópicos.
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