Introduction: Parkinson Disease (PD) although described initially by James Parkinson as a disease with motor disorder it has been demonstrated that the cognitive disorders in the form of disejecutive syndrome are frequent worsening with the evolution. Objective: To characterize the Frontal Dysfunction (FD) in the patients with PD and to determine the factors related with frontal dysfunction in early stages. Method: We studied 125 patients with diagnosis of idiopathic PD and Hoehn and Yahr Stages <2, to those which it was carried to them out survey with demographic, clinical and neuropsychological data studies included the Frontal Assessment Battery (FAB). Results: The mean age was of 68.1±8.6, the onset age was of 62.6±10.5, the diestrums predominated and those which initiated with tremor. Of the 125 patients 71.4% presented FD, with an average of the FAB of 11.82±3.7. The age (R=-0.45; p<0.001) and onset age (R=-0.33; p=0.02) showed inversely proportional correlation with the FD. Other related variables were the schooling up to second level (p=0.003) and the rural origin with significance <0.001. Conclusion: The age and onset age higher than 60 years, the lower schooling than second level of teaching, rural origin and the presence of cognitive dysfunction are related to FD in early stages of PD.

We report the history of two brothers who had early onset Parkinson (EOP) with blepharospasm, with family a history of Parkinson's disease. In both the neuropsychological examination showed cognitive deterioration with frontal lobe dysfunction. Patients with PLA2G6 mutation could show heterogeneous phenotype such as dystonia-parkinsonism (dystonia at onset affecting 14-57% of EOP patients and off period dystonia as affecting 30-59%), dementia and frontotemporal atrophy. Conclusion: In some genetic types of PD is produced from the beginning a degeneration of multiple systems with deficit in multiple neurotransmitters.

This work is licensed under Creative Commons Attribution 4.0 License ANN.MS.ID.000589.

This work is licensed under Creative Commons Attribution 4.0 License ANN.MS.ID.000607.

Parkinson's disease (PD) described for the first time in 1817 by James Parkinson, is kept as the second degenerative disorder of the central nervous system. The etiology and the pathogenic mechanisms of the PD are, and possibly will continue to be it during many years, strangers. This paper is the first of its type in our environment where we plan to determine the demographic and clinical manifestations of the patients with PD looked after in our center. We studied 118 patients with diagnosis of idiopathic PD attended on specialized consultation, since June 2010 to the same month of 2011, to those which it was carried to them out survey with demographic, clinical data studies included UPDRS, Hoehn and Yahr scales. Results: the greatest number of patients there contributed it Cienfuegos (49%), there was greater frequency of the male sex on the feminine (71:47), the mean age of beginning was of 62 ± 9.9, and the mean evolution of 68 months, the greatest number of the UPDRS motor and the Hoehn and Yahr scale showed it the age group from 56 to 64 years. There existed predominance in the rural areas (81:37) and well water (71:47), in addition to of the white race (101:17), 18.8% of patients had family history of PD.