The functionalized silicon carbide (SiC) fillers are employed to fabricate silicon carbide/polyphenylene sulfide (PPS) composites by mechanical ball milling-compression molding method. The thermal conductive coefficient of the SiC/PPS composites with 40 wt% functionalized SiC is 0.934 W/ mK, 4 times higher than that of the original PPS. The mechanical properties of SiC/PPS composites are optimal with 5 wt% addition of SiC. Both the heat resistant and dielectric properties of the SiC/PPS composites are increased with the increasing addition of SiC. For a given SiC loading, the surface functionalization of SiC can improve the thermal conductivities and mechanical properties of the SiC/PPS composites simultaneously.

The polypropylene/aluminum nitride (PP/AlN) thermal conductivity composites were prepared by compression moulding method. Results revealed that the thermal conductivity of the composites were increased with the increasing AlN, and the thermal conductivity of composites was 1.84W/mk filled with 50vol% modified AlN. Both the tensile and impact strength of the composites increased firstly, but decreased with excessive addition of AlN. For given AlN loading, the surface modification of AlN exhibited a positive effect on the thermal conductivity. Meantime, the grafting of PP could increase the thermal conductivity of the composites compared with pure PP. And the addition of AlN did not change the crystal form of PP, but decrease the crystallinity of the composites.

Gliomas are the most common malignant tumors in the central nervous system. Evidence shows that alterations of the gut microbiome play an important role in multiple diseases including central nervous system disorders. However, the influence of gut microbiome to the epigenesis of gliomas remains largely unknown. Here we profiled the gut microbiome and metabolome in fecal samples from healthy volunteers and the patients with gliomas through the 16S rRNA gene sequencing and LC-MS analyses. The fecal samples from primary glioma patients (n=51), recurrent glioma patients (n=11), patients who underwent TMZ radio-chemotherapy (n=16) and healthy volunteers (n=37) were collected. 56 discriminatory OTUs and 144 metabolites were observed in gliomas compared to those in healthy volunteers, and some species were correlated with clinical parameters. Moreover, the gliomas group showed increased activity in pathways associated with ectoine biosynthesis, fatty acid elongation, and protocatechuate degradation. Random forest modeling indicated that a model involving 8 genera and 10 metabolite biomarkers achieved a high accuracy in gliomas prediction (AUC=94.4%). We investigated interassociations between the microbial genera in glioblastoma multiforme (GBM) and progression-free survival (PFS) and overall survival (OS) by Spearman's correlation analysis. Patients with high proportions of fecalFaecalibacteriumhad significantly better median PFS or OS than those with low proportions. Moreover, animal experiments have verified the causal relationship between the structural changes of gut microbiome and glioma growth. Our current study comprehensively characterizes the perturbed interface of gut microbiome and metabolites in glioma patients, which may be used as diagnostic and prognostic biomarkers of gliomas.