Graphene oxide (GO) and its functionalized derivatives have attracted increasing attention in medical treatment. Herein, a reduction sensitive PEI‐GO‐SS‐TPP was synthesized for photodynamic therapy. More than 80% porphyrin release was observed in the presence of 10 mmol•L−1 DTT in one day. The confocal laser scanning microscopy confirmed that the cell uptake efficiency of PEI‐GO‐SS‐TPP was remarkably enhanced as compared to free porphyrin which was significantly dependent on incubation time. For photodynamic therapy, GSH‐OEt could effectively increase the photodynamic therapy efficiency of PEI‐GO‐SS‐TPP. Compared with free porphyrin, the toxicity from PEI‐GO‐SS‐TPP is much higher with a low IC50 (2.1 µg/mL) value. All results indicate that the PEI‐GO‐SS‐TPP PSs are promising for photodynamic therapy.

Introduction High-intensity swimming requires athletes to have explosive power, endurance, lactic acid resistance, aerobic metabolism, and other qualities. Pre-competition physical training is mainly based on high interval training, promoting ATP-CP synthesis in the body. It can enhance the resistance to lactic acid and promote lactic acid clearance. Objective This article explores the effect of high-intensity pre-competition training on the physical fitness of swimmers. The results can be used as a reference for swimmers to perform high-intensity training before the competition. Methods Eight swimmers were selected by random sampling. The study subjects received eight weeks of high-intensity training before the competition. The athletes’ gas metabolism and anaerobic thresholds were detected before and after training. At the same time, the physiological and chemical indicators of the experimental subjects were detected in this paper. Finally, this paper analyzes the experimental results by employing mathematical statistics. Results The metabolism function of the athletes changed significantly in the later period of pre-competition training (P<0.05). Serum lactate concentration had no significant effect on the anaerobic threshold (P>0.05). Conclusion High-intensity exercise has a particular promotion effect on improving the physical quality of swimmers. This exercise can lay a solid foundation for the swimmer’s physical fitness. Level of evidence II; Therapeutic studies – investigation of treatment results.

To promote the integrated development of the sports and tourism industry, create new formats, and drive the development of five happiness industries as tourism, culture, sports, health, and elderly care, promote local industrial layout and high-quality development, the author proposes an optimization model for the integration of sports industry digitalization and tourism industry. Based on the coupling coordination theory and fusion theory, the author chooses city A as the research case, through the coupling analysis method, the integrated development level of the sports industry and the tourism industry in City A was discriminated, and the dynamic factors and hindering factors affecting the coupling were explored, and the reasons were analyzed. The results show that the index weights of the two system layers, namely, the sports and tourism industry system layers, are 0.5 and 0.5, respectively. The top five weighted indicators are The number of sports-related enterprises, the number of tourist attractions, the number of travel agencies, the number of sports professionals and the number of domestic tourists received; The results of the coupling coordination degree show that in terms of degree D, there is an obvious trend of long-term stable linear increase and then a small decline, from 2010 to 2019, the D value increased from 0.28 to 1. Conclusion: The model is suitable for the practical framework of the development trend of the sports tourism industry model.