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The purpose of this study was to investigate the level of spirituality and stress of clinical practice and to identify the relationship of variables among nursing students. Data were collected from 203 nursing students using self-report questionnaire composed of demographic characteristics and two scales including spirituality and stress of clinical practice. Data were analyzed by frequencies, t-test, ANOVA, Pearson's correlation coefficients using the SPSS program. The mean score for spirituality and stress of clinical practice were above medium level, with the value of 3.18 and 3.42 out of 5 respectively. There were significant mean differences in spirituality according to religion and satisfaction on major while those in stress of clinical practice according to sex and satisfaction on major. Significant negative correlation between spirituality and stress of clinical practice was found. In conclusion, to reduce clinical stress in nursing students, it is necessary to develop and apply educational program for spiritual improvement.

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