Abstract. B-cell lymphoma-extra large (Bcl-X l ) has been known to suppress serum deprivation-induced cell death, while reactive oxygen species modulator 1 (romo1) is responsible for a serum deprivation-induced increase in reactive oxygen species (ros). therefore, we investigated whether Bcl-X l expression could inhibit the serum deprivation-induced increase in ros and cell death, which are mediated by romo1. We found that Bcl-X l expression effectively blocked serum deprivation-and romo1-triggered ros generation. Bcl-X l also inhibited apoptotic cell death induced by both serum deprivation and oxidative stress. From these results, we suggest that increased Bcl-X l expression, which is observed in many cancer cells, confers resistance to oxidative stress in the cancer cells by suppressing romo1-mediated oxidative stress.

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