Serum concentrations of luteinizing hormone (LH), testosterone, prostatic acid phosphatase (PAP) and prostatic specific antigen (PSA) were measured in 16 patients with advanced prostatic cancer before and after treatment with luteinizing hormone-releasing hormone (LHRH) analogue. An initial rise of serum LH and testosterone levels was observed on day 2 of the treatment. Subsequently, serum concentrations of PAP and PSA showed a transient increase on day 5 of the treatment. This indicates that LHRH analogues had better be given in combination with antiandrogens in patients with metastatic carcinoma of the prostate.

Serum concentrations of prostatic acid phosphatase (PAP), Γ-seminoprotein (Γ -Sm) and prostatic specific antigen (PSA) were measured in 31 hemodialysis patients without clinical signs of malignant disease. PAP, Γ -Sm and PSA levels in serum were not significantly different between control and hemodialysis groups. A significant reduction in these tumor markers was not found after dialysis treatment. This indicates that the measurement of PAP, Γ -Sm and PSA in serum is useful for the detection of prostatic cancer in patients undergoing hemodialysis.

ABSTRACT:The polymerization and crosslinking reaction mechanisms were studied for the emulsion polymerization of chloroprene. The dependence of volume of monomer droplet, surface-tension and crosslinking density on conversion was confirmed to be corresponding to the Harkins and Smith-Ewart models. Crosslinking densities were estimated from swelling ratios of the gel polymers prepared at various temperatures in the absence of a chain transfer reagent. The ratios of the rate constant of the propagation to the crosslinking Kwere calculated to be 2.0 x 10-4 , 7.1 X 10-4 , and 9.9 X 10-4 at 10, 40, and 55°C, respectively. The difference between activation energies of these two mechanisms was 27.8 kJ mol-1 . The proportions of polymer in the growing polymer particles during the existence of monomer droplets B' were also caluculated to be 0.47, 0.45, and 0.42, at each temperature.

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A case is presented of a 40 y.o. female with Cushing's syndrome. Her plasma glucocorticoid values were elevated (11-deoxy-cortisol: 3.46 ng/ml, cortisol: 25.6 micrograms/dl and cortisone: 35.7 ng/ml) with loss of diurnal variation. Urine 17-OHCS value failed to b suppressed by high dose dexamethasone and was unchanged after metyrapone administration. Her plasma mineral corticoids and androgens were within normal limits. There were 3 separate tumors in the right adrenal on CT and the left adrenal had no uptake on 131I-adosterol scintigram. We, therefore, diagnosed her illness as Cushing's syndrome due to unilateral multiple adenomas. Gross and histological examination of the right adrenal revealed one compact cell dominant adenoma and two clear cell dominant adenomas. This is the 4th case of Cushing syndrome due to unilateral multiple adrenal adenomas in Japan.