Allenol has been identified as a versatile building block for organic synthesis, and numerous efforts have been made to synthesize and apply allenol. However, limited efforts have been made to obtain a trifluoromethyl-substituted allenol. Here, by using a readily available 1,3-enyne as the starting material, a coppercatalyzed trifluoromethylbenzoxylation process was developed for efficient synthesis of trifluoromethyl-substituted allenols using Togni-II reagent as the reaction partner. Triple roles of the Togni-II reagent, including as the source of the trifluoromethyl group, as the source of the hydroxyl group, and as the oxidant, were elucidated in this transformation. Moreover, late-stage diversification was performed, which revealed the application potential of trifluoromethyl-substituted allenols for the preparation of various trifluoromethyl-substituted compounds.

The applications of peptides and peptidomimetics have been demonstrated in the fields of therapeutics, diagnostics, and chemical biology. Strategies for the direct late-stage modification of peptides and peptidomimetics are highly...

At hiol-aldehyde polycondensation … …w as developed for the polymerization of phenolic compounds.I nt heir Research Article (e202305677), Shichao Xu, Liang Yuan et al. found several catalysts for making linear and network-structured phenolic polymers from plant-derived monomers.S ince the repeating units are connected via dynamic dithioacetal groups,t he cross-linked networks can be reprocessed and oxidatively degraded by DMSO to recover the monomers for reuse.

hiol-aldehyde polycondensation … …w as developed for the polymerization of phenolic compounds.I nt heir Research Article (e202305677), Shichao Xu, Liang Yuan et al. found several catalysts for making linear and network-structured phenolic polymers from plant-derived monomers.S ince the repeating units are connected via dynamic dithioacetal groups,t he cross-linked networks can be reprocessed and oxidatively degraded by DMSO to recover the monomers for reuse.