ABSTRACT Combining the idea of quantum secure communication and quantum homomorphic signature, we propose a quantum secure communication protocol with signature via EPR pairs, in which the identities of the sender and the recipient could be certified and the integrity of the message transmitted is guaranteed according to their signatures. Comparing with the previous quantum secure communication scheme without signature, our protocol is not only feasible in practice but also can effectively guarantee the reliability and security of the quantum communication. The security of the protocol is analyzed.