Salinomycin is a new polyether antibiotic produced by a strain of Streptomyces albus (ATCC 21838). The antibiotic is purified by solvent extraction followed by chromatography on alumina or silica gel. It is a weakly acidic compound and has the molecular formula C42H70O11. Salinomycin exhibits activity against gram-positive bacteria including mycobacteria and some filamentous fungi. and is effective in the treatment of coccidial infection of poultry. During the course of our screening program for new antibiotics, a new biologically active substance has been isolated from the culture broth of a strain of Streptomvices (No. 80614). This substance was designated as salinomycin. Salinomycin is a member of the polyether antibiotics, which include nigericin1), K-1782), K-3583), X-2064), lasalocid (X-537A)5), grisorixin6), monensin7), dianemycin8) and A204A9), but it can be differentiated clearly from the above compounds on the basis of the chemical and spectral properties. As a result of taxonomical study, the salinomycin-producing organism was identified as a strain of Streptomyces albus (Rossl-DORIA) WAKSMAN and HENRICi, and the type strain has been deposited in the Fermentation Research Institute

A new crystalline antibiotic, minimycin1), C9HnNO7,was isolated from the culture broth of Streptomyces hygroscopicus. Isolation and properties of the new antibiotic are described. Minimycin is active against both Gram-positive and Gram-negative bacteria, and also possesses significant antitumor activity against transplantable tumors.

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