An Expedient Synthesis of cis/trans-1,3-Disubstituted Cyclobutanols. -3-Alkoxycyclobutanones such as (IV) are obtained from [2 + 2] cycloaddition of alkyl vinyl ether and chloroketene followed by hydrogenolytic dechlorination. They can be converted to trans 1,3-disubstituted derivatives [cf. (VI)]. -(CALAD, S.; MANS*, D.; MORIN, J.-A.; O'NEILL-SLAWECKI, S.; SISKO, J.; Tetrahedron Lett. 52 (2011) 32, 4207-4210, http://dx.
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