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A series of l-methyl-2-(2-aminoethyl)-piperidines (III) and their bis-quaternary ammonium salts have been prepared and evaluated as hypotensive agents. The majority of the bis-quaternary salts have been found to be hypotensive agents of the ganglionic blocking type. The most active of these bis-quaternary salts were the two isomers of l,l-dimethyl-5-ethyl-2-(2-morpholinoethyl)-piperidinium iodide methiodide. Nuclear magnetic resonance studies have allowed the assignment of the trans configuration to the high-melting isomer and the cis configuration to the low-melting compound.

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