In 1971, Folkman showed that tumour growth was dependent on the formation of new blood vessels (Folkman, 1971), a process known as angiogenesis. Angiogenesis in carcinomas often correlates with the likelihood of the development of metastases and the prognosis of patients (Folkman, 1995). A number of different angiogenic and anti-angiogenic factors are known to be involved
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