The pharmacokinetics of risperidone was affected by the concomitant administration of ketoconazole. If a CYP3A4 inhibitor is used concomitantly with risperidone, it is necessary for the clinicians to monitor their patients for signs of adverse drug reactions.

To improve resolution power of chiral selector and enantiomeric peak efficiency in CE, single isomer negatively charged β-CD derivatives, mono(6-deoxy-6-sulfoethylthio)-β-CD (SET-β-CD) bearing one negative charge and mono[6-deoxy-6-(6-sulfooxy-5,5-bis-sulfooxymethyl)hexylthio]-β-CD (SMHT-β-CD) carrying three negative charges, were synthesized. The structure of these two β-CD derivatives was confirmed by (1)H NMR and MS. SET-β-CD and SMHT-β-CD successfully resolved the enantiomers of several basic model compounds. SMHT-β-CD provided for a significantly greater enantioseparation than SET-β-CD at lower concentrations. This appears to be due to the higher binding affinity of SMHT-β-CD to the model compounds and the wider separation window resulting from an increased countercurrent mobility of the selector. Overall, the new chiral selectors provided enantioseparations with high peak efficiency while avoiding peak distortion due to polydispersive and electrodispersive effects. The information obtained from an apparent binding constant study suggested that the enantioseparation of the model compounds followed the predictions of charged resolving agent migration model and that the observed degree of enantioseparation difference were due to the magnitude of differences in both enantiomer-chiral selector binding affinities (ΔK) and the mobilities of the complexed enantiomers (Δμ(c)).

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A simple and sensitive high-performance~Uquid chromatographic method for the determination of spiked 2 methoxy-1,4~naphthoquinone in human plasma has been innovatively developed.A C18 reversed-phase column was used with a mobile phase consisting of methanol-acetate buffer p 4.0 (55 : 44 v/v) and UV detection at 275 rim. 2-Methyl-l,4-naphthoquinone was u ed as an internal standard.