The ISPA still remains an important issue, since it caused deaths on babies and infants at about one of four deaths occurred. Therefore, the Program Pemberantasan Penyakit ISPA (P2ISPA) must be conducted on Puskesmas level. The effort on the ISPA Eradication Program in Indonesia was launched in 1984 alongside the WHO’s global program. In order to achieve better implementation on it, good management is needed to reach the desired goals. The aim of this study is to describe: 1) the planning function of the program; 2) the organizational function of the program; 3) the implemental function of the program; 4) the supervising function of the program. The type of study is descriptive research with a qualitative approach method. The population is 15 officers of Puskesmas Pasir Panjang that also taken as a sample. There is a supervising function though with a minimum scope of the service area, as observed, and only at the Puskesmas by the Dinas Kesehatan Kota and no proper evaluation program. It is necessary to improve the planning function, the implementing and supervising function, a continuous effort on information spreading, and cross-field networking.