No abstract

RESULTS: For 23 embryos diagnosed as aneuploid by initial TE biopsy, 78.3% of initial TE samples, 87.0% of TE re-biopsies and 78.3% of BCM samples were concordant with corresponding ICM samples (P>0.05); but for 3 mosaic embryos, the concordance rates with ICM of these three groups were 0%, 100% and 100% (P<0.05), respectively. With the corresponding ICM result as the true result, sensitivity of both niPGT-A and initial TE were 100%; but the FPR of initial TE was higher than that of niPGT-A (100% vs. 0, P¼0.100).CONCLUSIONS: NiPGT-A using spent BCM had similar diagnostic efficiency as TE-biopsy PGT-A. And in case of mosaic embryos, niPGT-A using BCM may be more reliable for predicting the karyotypes of ICM than initial TE biopsy.