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The e f f e c t o f re-compression on t h e t a b l e t i n g p r o p e r t i e s o f some d i r e c t compression e x c i p i e n t s ( d i r e c t l y compressible s t a r c h , d i c a l c i u m phosphate d i h y d r a t e and m i c r o c r y s t a l l i n e c e l l u l o s e ) and t h e i r f o r m u l a t i o n s was examined. Re-compression g e n e r a l l y reduced t h e t a b l e t s t r e n g t h and t h i s r e d u c t i o n was more s i g n i f i c a n t when t h e i n i t i a l compaction was c a r r i e d o u t a t a h i g h e r pressure. The reason f o r t h e r e d u c t i o n of t e n s i l e s t r e n g t h upon re-working i s a t t r i b u t e d t o work hardening and t h e p r o d u c t i o n o f r o b u s t granules, which have i n c r e a s e d r e s i s t a n c e t o d e f o r m a t i o n compared t o unworked granules. Company L i m i t e d , Nottingham. Copyright 0 1983 by Marcel Dekker, Inc.331 0363-9045/83/0903433 1 $3.50/0 Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Melbourne on 11/16/14For personal use only.

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