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The antidiarrhoeal effect of the water extract of Melastoma malabathricum Linn. (Melastomataceae) leaves were investigated by employing four experimental models of diarrhea in Swiss mice. Melastoma malabathricum water extract treated mice showed significant reduction in the fecal output and protected them from castor oil-induced diarrhoea. The extract also reduced the intestinal fluid secretion induced by magnesium sulphate and gastrointestinal motility after charcoal meal administration in the mice. No mortality and visible signs of general weakness was observed in the mice following the test extract administration up to 2000 mg/kg dose.

This work was carried out in collaboration between all authors. Authors KA and JAJS designed the study. Author KA develop the protocol and wrote the first and second drafts of the manuscript. Authors KA and JAJS performed the experimental works. Authors TVA, RA and SK involved in the collection of literature, interpret the results and performed the statistical analysis. All authors read and approved the final manuscript.

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