Introduction. The article deals with the main provisions concerning the implementation of the constitutional right of employees on the protection of their life and health in the process of labor activity, on appropriate, safe and healthy working conditions, regulation of the relationship between the employer and the employee on safety and health issues, the working environment and the establishment of a unified procedure for the organization of labor protection in Ukraine, with the competent state authorities involved. Problem Statement. The paper presents the results of problems analysis related to the development of modern urban center as a service infrastructure network taking into account the work safety at workplaces.Purpose. To provide the service infrastructure employees with high-quality and safe working conditions (in terms of noise factor and air pollution by exhaust gases from motor vehicles along D. Yavornytskyi Avenue) in the downtown of the Dnipro city. Materials and Methods. Information on the noise and air pollution from motor vehicles and the number of workplaces within the studied territory has been obtained from field observations.Results. The noise pollution in 2 meters from the first echelon building facades on D. Yavornytskyi Avenue varies from 72 dBА to 75 dBА. The concentration of exhaust gases ranges from 15 to 35 mg/m 3 . It has been established that in the city center, there are 6000 m 2 commercial space of public and social and infrastructure, where 330 employees of various occupations are working.Conclusions. The dynamics of changes in the traffic load on D. Yavornytskyi Avenue from 2011 through 2017 has been studied. The equivalent noise level and the exhaust gas concentration ССО at work places have been established to exceed the norm by 9-19 dBA and by 15-30 mg/m 3 , respectively. K e y w o r d s: public city center, traffic load, service facilities, and workplaces.