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SUMMARY The results of a 12-month blind randomised trial comparing the intraocular pressure lowering effect of timolol 0 25% with timolol 05% are presented. 27% In addition it has no intrinsic sympathomimetic or local anaesthetic activity.4Timolol appears to lower intraocular pressure by decreasing aqueous production rather than by increasing aqueous outflow. A reduction in aqueous inflow of 13-48% has been demonstrated by fluorophotometry.5Several short-tern studies undertaken to investigate the ocular hypotensive effect of various concentrations of topical timolol have indicated that the lowering of intraocular pressure may be maximal at a concentration of timolol 0 25%.367 In a significant number of patients receiving continuous topical timolol therapy a gradual reduction in the efficacy of timolol (with regard to lowering of intraocular pressure) appears with time (often called 'long-term drift').This study was undertaken to investigate 2 particular parameters of the therapeutic effect of timolol in open-angle glaucoma. The study attempts to establish the reduction in intraocular pressure which is produced and sustained by the 2 commercially Correspondence to Mr K. B. Mills. FRCSEd. available concentrations of timolol solution (namely, 0 25% and 0 5%) and whether there is a statistically significant difference between the 2 concentrations, when the reduction in intraocular pressure is compared, after continuous long-term topical instillation. Secondly, this study attempts to provide further information on the incidence and importance of the phenomenon of long-term drift. Materials and methods

Most UK surgeons believed that during cataract surgery under local anaesthesia, patients might experience various visual sensations which could cause fear and that such fear could be alleviated by preoperative counselling.

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