No abstract

Medicpal leeches (Hirudo medicinalis) and the native secretion of their sali-vary glands diluted with saline (5 times) were successfully used for the treatment of some ear diseases: tinnitus caused by inner-ear affections, acute external otitis and chronic Otitis media. The effect of diluted leech saliva injected into the region of the mastoid process by microelectrophoresis was 25-30% lower than that of the medicinal leeches.

Antiprocoagulant complex isolated from lyophilized medicinal leeches exerted pronounced antithrombotic, thrombolytic, and hypotensive effects in experimental animals after intravenous injection and showed antithrombotic activity after oral administration in combination with hirudone, the source of hyaluronidase and inhibitors of digestive proteolytic enzymes, The antiprocoagulant complex can be used as a specific medicinal preparation.