A low molecular weight isoform of hyaluronidase (NNH2) has been isolated from Indian cobra (Naja naja) venom by successive chromatography on Sephadex G-75 and CM-Sephadex C-25 columns. The apparent molecular weight determined by SDS-PAGE is 52 kD, and the pI value is 9.7. NNH2 is an endoglycosidase and exhibits in vitro absolute specificity for hyaluronan; it also hydrolyzed hyaluronan in human skin sections. NNH2 is nontoxic, but it indirectly potentiates the hemorrhagic activity of hemorrhagic complex-I. Curcumin, indomethacin, and tannic acid inhibited dose dependently the degradation of hyaluronan by NNH2.

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Background: Prompt-L-Pop is a sixth generation bonding system contains methacrylated phosphoric acid esters that combine an acidic component for etching the enamel and a primer, is an all-in-one adhesive. This study was undertaken to compare the bonding strength of brackets to enamel with traditional bonding technique and the new Prompt-L-Pop system using the same composite resin.

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