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In order to evaluate the bone-implant integration behavior of biodegradable calcium metaphosphate (CMP, [Ca(PO 3 ) 2 ] n ) coated metallic implant, as-machined, blasted, and blasted /CMP-coated Ti6Al4V screw-type implants were prepared and aseptically implanted into male New Zealand white rabbits. CMP sol was prepared by sol-gel process and coated on each substrate by dip and spin coating. The CMP coated layer was smooth and uniform with fine grains, compared to that of as-machined and as-blasted specimens. Each specimen was inserted into the defects of bilateral intratibial metaphysis bone and then followed up for 1 and 6 weeks. From the radiographs at 1 and 6 weeks after implantation, all the implants were shown to be apparently well integrated with surrounding bone tissue without interfacial fracture, bony resorption, or radiolucent lines. With the combination of histological results, CMP-coated group was noticed that bony bridges were extending from the endosteum onto the implants at 6 weeks after implantation, with the showing good osseo-intergration compared to other two groups.

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