Traditional medicines are most commonly used to meet the health care needs especially in developing countries. Gynura cusimba (D.Don) Moore has been traditionally used as a medicinal plant for healing wounds, headache and as anti-ulcer for centuries. The present study was taken to evaluate the antiinflammatory properties in suitable animal experimental model. Antiinflammatory activity of the aqueous extract of the plant was observed using carrageenan induced rat paw oedema. The foot/paw volume was measured by the modified plethysmographic method. The test drug at doses of 500,1000 and 2000mg/kg produced 16.67%, 33.34% and 44.44% inhibition of paw oedemas compared to 72.29% inhibition produced by the standard drug, Aspirin. It thus showed a significant antiinflammatory activity.