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Parkinson's disease (PD) is a neurological progressive disorder and is most common among people who are above 60 years old. It affects the brain nerve cells due to the deficiency of dopamine secretion. Dopamine acts as a neurotransmitter and helps in the movement of the body parts. Once brain cells/neurons start dying due to aging, then it will lead to a decrease in dopamine levels. The symptoms of Parkinson's are difficultly in doing regular/habitual movements, uncontrollable shaking of hands and limbs may encounter memory loss, stiff muscles, sudden temporary loss of control, etc. The severity of the disease will be worse if not diagnosed and treated at the early stages. This paper concentrates on developing Parkinson's disease diagnosing system using machine learning techniques and algorithms. Machine Learning is an integral part of artificial intelligence it takes huge data as input and train by making use of existing algorithms to understand the pattern of the data. Based on the recognized pattern, the machine will act accordingly without any human intervention. In this work, two major approaches have been employed to diagnose PD. Initially, 26 vocal data of PD affected and healthy individual datasets are obtained from the UCI Machine Learning data repository, are taken as initial raw data/features. In pre-processing, the mRMR feature selection algorithm is employed to minimize the feature count and increase the accuracy rate. The selected features will further be extracted using the Stacked Autoencoder technique to improve and increase the accuracy rate and quality of classification with reduced run time. K-fold cross-validation is used to evaluate the predictive capability of the model and the effectiveness of the extracted features. Artificial Immune Recognition System -Parallel (AIRS-P), an immune inspired algorithm is employed to classify the data from the extracted features. The proposed system attained 97% accuracy, outperforms the benchmarked algorithms and proved its significance on PD classification.

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