Red ginger with superior content of 6-shogaol, 6-gingerol, and gingerdion are commonly used as traditional medicines that are useful for the health of the body and have a high market demand. Satisfaction of market interest for red ginger should be possible utilizing ideal and reasonable development innovation. This study aims to obtain a substitution of NPK fertilizer with Dirjanik as organic fertilizer that gives better results. The study was carried out in Pelem, Wonorejo, Jatiyoso, Karanganyar, Indonesia during March to July 2021. The experiment was using a one-factor randomized complete block design (RCBD), five levels, 5 replications, namely D0 (100% NPK), D1 (75 % NPK + 25% organic fertilizer), D2 (50% NPK + 50% organic fertilizer), D3 (25% NPK + 75% organic fertilizer), and D4 (100% organic fertilizer). Data analysis used orthogonal contrast (5% F test) variance to obtain differences between organic fertilization and other fertilizers, as well as differences between substitution doses. The results showed that D2 fertilization gave higher plant growth in the form of number of leaves, number of stems per clump, and biomass. D3 fertilization gave higher yields per plot in the form of rhizome thickness, fresh weight (1.4 tons ha−1), and rhizome storage weight (1.2 tons ha−1). Fertilization 100% organic/7,419.4 kg ha−1 organic fertilizer effect on the yield of fresh weight and storage weight per clumsp higher.