Most of the standard methods of treatment of patients with inflammatory nose and paranasal sinuses diseases are not effective enough. Argogel is a topical nanotechnology-based preparation which could be a conservative therapeutic alternative for such patients. The objective of this study was to evaluate the efficacy of topical application of the preparation containing silver nanoparticles in the early post-surgery period of the nasal cavity and paranasal sinuses. The study covered 40 patients with chronic rhinosinusitis aged from 25 to 70 after the ambilateral endoscopic maxillary ethmoidotomy. In the course of treatment on most of the patients, Argogel preparation application was accompanied with rapid improvement of objective state, normalization of rhinoscopic pattern and rhinocytogram results in comparison with application of the ointment Levomekol. This tendency has been observed over the whole treatment period.