Direct numerical simulation of a fully developed turbulent flow of a viscous compressible fluid containing spherical solid particles in a channel is carried out. The formation of regions with an increased concentration of solid particles in a fully developed turbulent flow in a channel with solid walls is considered. The fluid flow is simulated with unsteady three-dimensional Navier – Stokes equations. The discrete trajectory approach is applied to simulate the motion of particles. The distributions of the mean and fluctuating characteristics of the fluid flow and distribution of the concentration of the dispersed phase in the channel are discussed. The formation of regions with an increased concentration of particles is associated with the instantaneous distribution of vorticity in the near-wall region of the channel. The results of numerical simulation are in qualitative and quantitative agreement with the available data of physical and computational experiments.