In two experiments, a high dietary level of available phosphorus (.65%) in the presence of high chloride concentrations (.36%) was associated with a significant increase in the incidence of tibial dyschondroplasia (TD) in male broiler chickens. The level of dietary calcium and the interaction between Ca and available P had no effect on TD. Heterozygous normal (DW/DW) male broilers had a significantly lower incidence of TD than homozygous normal (Dw/Dw) chicks (Experiments 1 and 2). In Experiments 3 and 4, there were no significant differences between BW at 14 days for roaster-broiler cross and broiler chicks. At 21 and 28 days, however, the roaster-broiler cross chicks weighed significantly less than the broilers and had a significantly lower incidence of TD. Decreasing growth rates in broiler chicks after 14 days of age resulted in a significant decrease in the incidence of TD (Experiments 4 and 5), but did not decrease the severity of TD lesions at 28 days (Experiment 5). Depressed growth from 0 to 14 days decreased, but did not eliminate, TD lesions (45%) at 28 days, but it did significantly decrease the severity of the lesions compared with that in the 14 to 28-day manipulation treatments (Experiment 5). In Experiment 5, chicks were growth restricted from 0 to 14 or 14 to 21 days and then ad libitum fed the control diet until 28 days of age. The serum growth hormone concentrations at 28 days were inversely related to the rate of BW gain from 21 to 28 days of age, independent of BW at 21 or 28 days or feed consumption from 21 to 28 days. There were no differences in serum concentration of thyroxine or triiodothyronine at 28 days.