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We examined the expression of the transglutaminase 1 (TGase 1) gene in frozen sections of normal and psoriatic epidermis by means of non-radioactive in situ hybridization with digoxigenin-labelled cRNA probes. TGase 1 mRNA was expressed in the granular layer of normal epidermis, regardless of ortho- or hyperkeratosis. However, in psoriatic epidermis, TGase 1 mRNA was detected in the suprabasal spinous layer, but not in the subcorneal layer. These results indicate that TGase 1 gene expression is limited to the last stage of keratinization in normal epidermis and this regulation is disturbed in psoriasis.

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A 73·year-old man, who developed bacteremia in the course of generalized pustular psoriasis (GPP) which appeared one year after the onset of psoriasis vulgaris, was reported. Blood culture confirmed bacteremia caused by Staphylococcus aureus, Epidermidis and Streptococcus faecalis. We emphasized in this article that bacteremia should be considered in emaciated patients with GPP who have received corticosteroid therapy for a long time, show remarkable shift to the left of neutrophils, and suffer remittent fever.