Grass carp were exposed to two therapeutic concentrations of copper sulfate (10 mgxL-1 in 1 hour and 1 mgxL-1 in 24 hours). Twenty-four hours after the copper sulfate baths, the histopathology of the gills was studied. The observed lesions in gills after short and long term baths were: mucus coagulation and accumulation of cellular debris on the epithelium of lamellae and inter lamellar regions, lamellar edema, hemorrhage, hyperplasia, epithelial cell necrosis, congestion and aneurysm (telangiectasis) in the secondary lamellae. In the 24 hour copper sulfate bath, the percentage of gill lesions that were observed correlated directly with the copper sulfate concentration (p0.05). Epithelial necrosis (89% in 10 mgxL-1 for 1 h) was the most prevalent lesion in these groups.
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