The item offers a view at the changes taking place in the immunologic responsiveness and the indices for the prooxidant-anti-oxidant system in the blood and in the oral liquid in case of T2D and IHD. There has been a significant IgA increase detected in the oral cavity in cases of T2D coming along with IHD (2.1 times), and IgM-at T2D (4 times). An imbalance has been found in the pro-oxidant-anti-oxidant system, accompanied by an increase in products of oxidative modification of biomolecules and decreased activity of catalase and superoxide dismutase in blood and oral liquid, especially in case of T2D comorbid with IHD. There has been significant correlation links established between the indices of immunologic responsiveness and the enzymes of anti-radical protection in blood and in oral liquid, as well as direct reliable correlation links between clinical indices for periodontal status and the indicators of non-specific protection in the oral cavity (r=±0,76-0,99).

The aim was to investigate prooxidant-antioxidant system in the blood and brain homogenates functional activity in rats with acute hypoxia model with different deuterium/protium (D/H) ratios in drinking diet. Studies have shown that consuming DDW (–665 ‰) within 8 weeks lead to deuterium concentration decrease in blood plasma at 317 ‰ and brain at 209 ‰ of rats, in comparison to control group, consuming natural water. DDW consumption before hypoxia modeling in rats improves antioxidant defense enzymes (catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase) activity in the blood, increasing its antioxidant potential by 20 %, while free radical oxidation intensity in plasma and biomolecules peroxide modification rate in erythrocytes. Also, in brain tissues consuming DDW, there were no abnormalities in catalase, superoxide dismutase activity, and it was noted increase (by 71 %) in reduced thiol-containing compounds concentration, which reduces nerve hypoxi? cell damage risk. Neuroprotective effect presence is confirmed by higher (by 32 %) antioxidant activity markers of lyophilized brain tissues, and by free radical oxidation lower intensity (by 13 %) and biomolecules oxidative modification rate (by 16 %) in these lyophilized tissues. Thus, the advisability of using DDW neuroprotective effects in cerebral circulation disturbance in experimental and clinical practice.

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ОсложненияComplications нижение вариабельности сердечного ритма (ВСР) является предиктором внезапной сер-дечной смерти, что было известно китайским врачам уже в третьем веке нашей эры: «Если пульс регу-лярен, как стук дятла или капель дождя о крышу, то па-циент умрет в течение четырех дней». В отечественной литературе до последнего времени изменения сердеч-ной мышцы у пациентов с нарушением углеводного об-мена именовали диабетической дистрофией миокарда, что было предложено еще в 1935 г. Лангом Г.Ф. [1]. ЭпидемиологияАнализ результатов эпидемиологических исследова-ний диабетической автономной нейропатии затруднен в связи с различием критериев отбора пациентов и ме-тодов исследования, что ведет к существенной разнице полученных результатов [2].Фактическая распространенность диабетической кардиоваскулярной автономной нейропатии (ДКАН) не установлена. Признается, что она зависит от воз-

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