The preparation is described of four
series of open-chain analogues of papaverine : N-alkyl-α-aminodeoxyanisoins, N-alkyl-2-amino-1,2-di-(p-methoxyphenyl)-ethanols,
N-alkyl-1,2-di-(p-methoxyphenyl)ethylamines, and N-alkyl-di-(p-methoxyphenyl)methylamines.
All of these showed spasmolytic activity and considerably lower toxicity than
papaverine.
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