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A detailed chemical examination of the Indian Ocean soft coral Sinularia flexibilis yielded two new cembranolide ε-lactones, sandensolide monoacetate (1) and flexibolide (4), in addition to the previously reported cembranolide δ-lactones, flexibilolide and dihydroflexibilolide, and the known cembranoid derivatives, sandensolide, cembrene A, and flexibilene. Their structures have been established by a study of their spectral data (UV, IR, 1H and 13C NMR, 2D NMR (1H−H, COSY and NOESY), and mass spectrometry.

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