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Herbal medicine has become a popular form of health care, globally. Herbal medicine is a preferred option nowadays even though few contrasts exist between herbal medicines and customary pharmacological medicines. Herbal formulations have been the most effective treatment for various disease conditions. Many studies have proved the efficiency of herb-herb combinations. In comparison with single drugs, drug combinations have shown a more promising effect in the treatment of disease. This drug combinations conception has been well established in many countries and extraordinary success has been reached. But not all the natural treatments are found to be inherently safe. A herbal formulation may carry risk. So, it is essential to know which herbal remedies do better than side effects and for which condition. Most herbal formulations are not properly standardized, and it lacks efficacy and safety for consumption. There has been numerous regulations and standard measure been taken in recent times to scrutinize the proper preparations of the herbal formulation will be effective and safe for consumption, with accordance to this it has paved the way for many advantageous benefits from the herbal formulation and curbing the non-beneficial effects of the available herbal formulations So, this review addresses the safety, efficacy, and regulations of herbal formulation.