Patients receiving a lopinavir/ritonavir and saquinavir dual protease inhibitor-based antiretroviral salvage regimen were studied to evaluate the pharmacokinetics, tolerability and efficacy of the regimen. Pharmacokinetic curves were obtained for lopinavir and saquinavir. Patient records were studied for adverse events and efficacy data. The pharmacokinetics of lopinavir and saquinavir were comparable with literature data, except for the saquinavir 0-12 h area under the curve and maximum concentration. The tolerability of the regimen was good and efficacy was encouraging.

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The plant extracts showed activity against one or more microorganism. Extracts which possessed 15-17 mm inhibition zones were considered to have a small activity. Average activity was considered when extracts possessed more than 18mm inhibition zones. Out of37 plant extracts screened, 30 plants (80%) were found to have an average antimicrobial effect. Phytochemical screening of the plant extracts showed the presence of tannins, flavonoids, sterols, and/or triterpenes and aromatic compounds. References

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