Özet: Bu çalışmada, Newcastle hastalığına karşı göze ve buruna damla yoluyla aşılanan civcivlerde oluşan antikor düzeyi ve bağışıklığın durumu karşılaştırıldı. Hayvanlar iki gruba ayrıldı ve gruplardan biri göze damla diğeri buruna damla yoluyla aşılandı. Periyodik olarak alınan kan numunelerine hemaglutinasyon inhibisyon testi uygulandı. Ortalama maternal antikor titreleri Log2 HI 5,03 olarak saptandı. HBI aşı virusu ile göze ve buruna damla yoluyla yapılan aşılamalsrda sırasıyla ortalama Log2 HI titresi 8,52 ve 8,96 elde edildi. LaSota aşı virusu kullanılarak her iki grup içme suyu yolu ile yeniden aşılandı. HB i aşı virusu göze damla+LaSota aşı virusu içme suyu ile aşılananlarda ortalama Log2 HI titresi 8,80 iken HBl aşı virusu buruna damla+LaSota aşı virusu içme suyu ile aşılananlarda da 9,06 olarak tespit edildi. Periyodik olarak 15 gün ara ile alınan kan nu .mnelerinde ise sırası ile birinci ve ikinci grupta 62. günde 6.40 ve 6.80, n. In this s,tudy, antibody Ievel and immunity produced in chicks vaccinated against Newcastıc disease via the eye drop and the nostril drop were compared. Chicks were divided into two groups; one group was vaccinated via the eye drop and the other group via the nostril drop. Blood samples taken periodically were assessed by haemaglutination inhibition test. Mean maternal antibody titre of chicks was determined as Log2 HI 5.03. Mean Log2 HI titres in chicks vaccinated with HB i vaccine strain via the eye drop and the nostril drop were found to be. 8.52 and 8.96, respectively. Each group were re-vaccinated via in drinking water with LaSota vaccine virus. Antibody titres in blood samples taken from re-vaccinated animals were 8.80 and 9.06 in groups received HB i vaccine virus via the eye drop+LaSota vaccine virus in drinking water and HB i vaccine virus via the nostril drop+LaSota vaccine virus in drinking water, respectively. The chicks were bled on each 15 consecutive days and antibody titres in groups i and 2 were .found to be 6.40 and 6.80 on the 62 nd day, 5.80 and 5.93 on the n th day, 5.20 and 5.33 on the nnd day, and 4.93 and 5.06 on the 1071hday.
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