The aim of this research was to formulate and evaluate mucoadhesive microspheres of Olanzapine drug to enhance bioavailability and enhance residence time. Olanzepine mucoadhesive microsphere prepared by using sodium alginate polymer and calcium chloride as a crosslinking agent. .Microsphere were prepared by using ionic gelation method. Microsphere with particle size in the range 656.4µm to 659 µm. were prepared by using ionic gelation method. Olanzapine (OLE) having extensive hepatic first pass metabolism and low bioavailability problem, Olanzapine microspheres were evaluated for mean particle size, the percentage yield, entrapment efficiencies, in-vitro release, in vitro mucoadhesive, FTIR, DSC, X-ray diffraction studies and stability study. Formulation F9 microspheres batch was found to be optimized and followed zero-order release kinetic .The optimized formulation was mucoadhesive in nature. Stability studies was carried out for F9 at a temperature of 40±2°C/ RH 75±5% formulation revealed that the drug behavior was within permissible limits.

The aim of this research was to formulate and pharmacodynamicaly evaluate Fluoxetine Hcl microsphere microspheres to enhance bioavailability and antidepressant activity. Fluoxetine HCl microsphere was prepared by using Eudragit Rs polymer Microsphere by using emulsion solvent evaporation Fluoxetine Hydrochloride comes under category of selective inhibitor of serotonin reuptake type of drug used for treating depression. It is practically soluble in water having to BCS class I and 72%. Bioavailability Fluoxetine HCl microspheres were evaluated for entrapment efficiencies, in-vitro release, in-vitro mucoadhesive, in-vivo FTIR, DSC, X-ray diffraction studies and stability study. Formulation F9 microspheres batch was found to be optimized and followed zeroorder release kinetic.The optimized formulation was mucoadhesive in nature and increased antidepressant activity. Stability studies was carried out for F9 at a temperature of 40±2°C/ RH 75±5% formulation revealed that the drug behavior was within permissible limits.