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Present investigation evaluated the impact of poly-herbal formulations comprising extracts of Zingiberofficinale, Curcuma longa, Aloe barbadensis, Citrus aurantium, Emblica officinalis and castor oilon wound healing activity using excision wound model and antiinflammatory activity using formalininduced pawedema method. Ointments containing 2, 4 and 6 % w/w of extracts were made and used in wound healing action and all the formulations significantly (p<0.01) reduced the wound area. Ointment of 6 % w/w has shown better results than 2 and 4 % w/w. These results were compared to that of the standard framycetin. Poly-herbal formulation-1, poly-herbal formulation-2 and poly-herbal formulation-3 were prepared and used at doses of 100, 300 and 500 mg/kg to determine antiinflammatory activity. All poly-herbal formulations significantly (p<0.01) inhibited formalin-induced rat paw edema. Poly-herbal formulation-3 displayed greater inhibition than poly-herbal formulations 1 and 2. These results were comparable to that of the standard diclofenac. Present work and previous studies on poly-herbal formulations corroborates that these are safer and effective in treating inflammation and wounds.

Over last 30 years pulsatile drug delivery system has achieved a lot of importance in drug delivery technology. And the reason why this pulsatile drug delivery is gaining importance is because of its strategy of delivering drug molecule at right place, right time. There are certain diseases which are controlled by biological clock of our body and follow circadian rhythms like congestive heart failure, asthma, rheumatoid arthritis ,osteoarthritis, inflammatory disorders and other hormonal disorders, for this type of diseases conventional solid dosage forms like immediate release tablets or modified dosage forms like sustained, controlled release tablets cant give the required therapeutic response and also for such diseases delivering the drug at right time in right amount is very important. And that task is accomplished by this pulsatile drug delivery system. These pulsatile drug delivery framework is planned by the organic mood i.e., biological rhythms of the body, and medication conveyance is worked with by as per disease cadence. The rule for the utilization of pulsatile drug delivery of the medications is the place where a consistent drug discharge isnt wanted. The principle for the utilization of pulsatile release of the medications is the place where a steady drug discharge isnt wanted, yet drug release must be planned in such a way that, quick medication discharge is accomplished after the lag time. Current review examined the clarifications for improvement of pulsatile drug delivery framework in accordane with body circadian rhythm, kinds of the illness during which pulsatile discharge is required, order, assessments, benefits, impediments.

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Fast dissolving tablet (FDT) is one such type of an innovative and unique drug delivery system which is swiftly gaining much attention in the research field of rapid dissolving technology. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for paediatric and geriatric patients. Fast dissolving Tablets are disintegrating and/or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. FTD contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fastdisintegrating tablets, as they may take up to a minute to completely disintegrate. FDTs formulations contain super disintegrants to enhance the disintegration rate of a tablet in the buccal cavity. This review describes the various advantages, limitations, desired characteristics, formulation aspects, super-disintegrate employed, technologies developed for FDTs, novel hole technology, evaluation tests, drugs used in fast dissolving tablets, marketed formulations and patented drugs.