A global catastrophe caused by the COVID-19 epidemic has had negative effects on both health and the economy. The coagulation system may be involved in the pathophysiology of COVID-19 since D-Dimer, a measure of hypercoagulability, is higher in COVID-19 individuals with severe illness. In order to determine whether there is a relationship between D-Dimer levels and disease severity, this study measured the levels of D-Dimer in COVID-19 patients with severe and non-severe disease. The average age of the 72 confirmed COVID-19 patients in the research was 52.85 10.65. Based on the severity, the individuals were split into two groups, and the levels of D-Dimer were measured in each group. In contrast to individuals with less severe symptoms, those with severe COVID-19 symptoms had considerably higher levels of D-Dimer, according to the study. Cough, fever, breathing difficulties, and gastrointestinal symptoms were also discovered in the study to be statistically significant in patients with severe symptoms. The most prevalent co-morbid conditions among the individuals were hypertension and diabetes. These results emphasise the significance of identifying patients at risk for poor outcomes, tracking their D-Dimer levels and suggesting that D-Dimer levels may be a helpful prognostic marker in COVID-19 patients.