Dry cow therapy (DCT) in the Netherlands changed from mainly blanket to selective antimicrobial DCT. This transition was supported by a national guideline, with the individual somatic cell count (SCC) at the last milk recording before dry-off as the main selection criterion for antimicrobial DCT. The aim of this retrospective observational study is to evaluate the SCC dynamics during the dry period at the herd and individual dry period level following the national transition from mainly blanket to selective antimicrobial DCT. At the herd level, we used 2 data sets to evaluate the SCC dynamics during the dry period: (1) a national data set containing 3,493 herds with data available from 2011 through 2015 and (2) a veterinary practice data set containing 280 herds with data available from 2013 through 2015. The herd level analysis was carried out using key performance indicators provided via milk recording (CRV, Arnhem, the Netherlands): the percentage of cows that developed a new intramammary infection (IMI) during the dry period and the percentage of cows cured of an IMI during the dry period. The effect of DCT at individual dry period level was analyzed with a mixed-effects logistic regression model based on 4,404 dry periods from 2,638 cows in 20 herds within the veterinary practice data set. For these 20 herds, individual SCC data from milk recordings and individual cow DCT were available from 2013 through 2015. No significant changes were observed to the SCC dynamics during the dry period at the herd level. The percentage of cows that developed a new IMI during the dry period ranged between 16 and 18%, and the percentage of cows cured from an IMI during the dry period ranged between 74 and 76%. At the individual dry period level, a low SCC at the first milk recording following a dry period was associated with the use of intramammary antimicrobial DCT with or without the concurrent use of an intramammary teat sealer [odds ratio (OR) = 2.16 and OR = 2.07, respectively], the use of DCT with an intramammary teat sealer only (OR = 1.35), and a low SCC at the last milk recording before dry-off (OR = 1.78). This study demonstrates that the selection of cows for DCT without antimicrobials based on SCC thresholds at the last milk recording is possible without significant changes to udder health and reduced the use of antimicrobials.