There is some evidence to indicate an association between ABCB1 rs1045642T and colorectal cancer risk in Asians. Compared with the ABCB1 gene SNPs rs1045642, rs2032582 or rs3789243 alone, combined haplotypes of several SNPs might be a better marker to determine the genetic influence on the susceptibility to colorectal cancer among Caucasians.

neoadjuvant chemotherapy) was significantly higher in tumour 4cm (65% vs 20%) (p¼0.0001). Definitive chemoradiation was more indicated in larger tumours, without statistical significance (75% vs 46%)(p¼0.4). Therapeutic discordance between the planned and the administered treatment was significantly higher in larger tumours (68% vs 18%) (p¼0.0001). Progression free survival was longer in smaller tumours (18±9.3 vs 11±12.1 months) without being statistically significant. However, median overall survival was significantly correlated with tumour size (41.7± 5.1 in 4 cm, 32.8±4.6 months in > 4 cm) (p¼0.04). The pattern of recurrence was not correlated to tumour size; it was locoregional in 30%, distant in 20% and both locoregional/distant in 50% in4 cm group vs 42%, 24%, and 34% respectively in tumour size> 4 cm (p¼0.6). Conclusion:When taking 4 cm as a cut-off value, tumour size influenced clinical presentation and management modalities. It may be considered as a prognostic factor in stage III NSCLC.

Conclusion: High expression of SCs is negatively correlated with tumor stage and survival, indicating its potential diagnostic and therapeutic value for operated NSCLC patients.

L1 targeted therapies. Conclusion: This data supports the feasibility of using an automated CTC processing system to detect and monitor PD-L1 and MHC I expression in patients with NSCLC. Ongoing efforts include expanding this patient cohort in larger clinical trials and transitioning this test into a clinical laboratory testing facility for regulatory approval and use as a clinically actionable diagnostic tool.