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the acidic amino acid(s) in CBP, can also explain the result of (4).47 Recently, the amino acid sequence of CBP was determined by Rychlik et al.48 The most unusual feature of the CBP is the high tryptophan content [4.7 mol % (seven residue)], while other initiation factors (elF-2, -4A, -4B, -4C, 5) vary from 0 to 1 mol % tryptophan.49 Furthermore, this CBP shows a high content of acidic amino acids (25 and 28 residues for Glu and Asp, respectively). This result adds further weight to the above-mentioned discussions.Finally, we want to introduce a report50 that demonstrates the importance of the present results: antibodies specific for methylated DNA elicited in rabbits recognize only a single-strand region of DNA containing m7G base, and its antigenicity is decreased or lost in parallel with the extent of the release of m7G residues. This means that m7G residues of methylated DNA play an im-(47) This type of hydrogen bond has been found in the ra'GMP-Lphenylalanine complex crystals32 and exists as a predominant form in the solution state:

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