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A Peutz-Jeghers P-J type polyp is a hamartomatous polyp that occurs in patients with P-J syndrome, but is rarely found as a solitary polyp in non-P-J syndrome patients 1 . There have been some reports of polyposis and cancerous transformation in patients with P-J syndrome, but few reports of solitary P-J type polyps containing cancer foci 2, 3 . We report here a rare case of a colorectal P-J type polyp showing the hamartoma-adenoma-carcinoma sequence in a non-Peutz-Jeghers syndrome patient. Case ReportA 48-year-old woman was admitted to our hospital for medical examination. Colonoscopy Abstract : Peutz-Jeghers P-J syndrome is an inherited disorder characterized by multiple hamartomatous gastrointestinal polyps, mucocutaneous pigmentation, and an increased risk of both digestive tract and non-digestive tract cancers. P-J type polyps are characteristic of P-J syndrome but rarely present as solitary polyps. Though cancerous lesions frequently develop from polyposis in P-J syndrome, reports of malignancy in solitary colorectal P-J type polyps are rare ; our literature search identi ed only two examples. This report describes a non-Peutz-Jeghers syndrome patient with a solitary P-J type polyp showing the hamartoma-adenoma-carcinoma sequence.

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