Background: Claudins mediate the trans-epithelial barrier function of epithelial tissues in vertebrates and invertebrates. Results: Proteomic and in vivo analyses of the claudin Megatrachea protein complex identify novel Megatrachea interacting factors.
Conclusion:The claudin Megatrachea interacting factors include members of the clathrin-mediated endocytosis and a novel putative scavenger receptor. Significance: This is a comprehensive analysis of a claudin interactome.
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