Introduction. Bronchopulmonary pathology occupies an important place in the structure of childhood morbidity. The issues of prevention, diagnosis and treatment in children with respiratory pathology are currently relevant. Obstructive bronchitis is a common condition in childhood. The significant prevalence of obstructive bronchitis among children is due to disorders in the immune system. Scientists are currently paying much attention to the study of the functioning of the immune system in children with bronchopulmonary pathology. In addition, clinicians are studying the effect of drugs on the activity of immunocompetent cells. The aggressive action of environmental factors, the pathological action of infectious pathogens can contribute to the severe course of the disease, as well as the development of complications. In this work, we studied the effect of immunomodulators on the activity of lysozyme and on the level of circulating immune complexes. Target. Study of the effectiveness of immunomodulators in the complex treatment of obstructive bronchitis in children. Material and methods. Immunomodulators were administered to 26 children aged 1 to 3 years with a diagnosis of obstructive bronchitis. The control group included 11 healthy children. Results. The data obtained reflect the effectiveness of the use of immunomodulators in the treatment of obstructive bronchitis in children. A comparative analysis of treatment with the use of immunomodulators and treatment according to the standard scheme was carried out. There were no side effects when using immunomodulators. Conclusion. Immunological data obtained during the initial examination reflect dysfunction of the immune system. Derinat and polyoxidonium help to optimize the parameters of the immune system. The data obtained in this study made it possible to recommend prescribing the immunomodulators Derinat and Polyoxidonium to children with obstructive bronchitis.