A highly efficient method for synthesis of difluoroarymethyl-substituted
benzimidazo[2,1-a]isoquinolin-6(5H)-ones using 2-arylbenzoimidazoles with α,α-difluorophenylacetic
acid as reaction substrates has been developed through radical cascade
cyclization. The advantage of this strategy lies in excellent functional
group tolerance to generate the corresponding products in good yields
under base- and metal-free conditions.
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