Introduction: Dytor plus tablet is a fixed-dose combination of torsemide and spironolactone used for generalized edema. TEN is a serious, potentially life-threatening dermatological disorder. Methods: Here we present a case report of a 47-year-old female who was on Dytor Plus (5/50 mg)therapy once daily for generalized edema; presented to dermatology outpatient department with chief complaints of multiple erosions over oral cavity, swelling of lips with scaling, redness and burning sensation in both eyes, multiple well defined mostly erythematous rashes over the entire body since 2 days. Results: On examination, her vital signs were stable and lab results indicate she had elevated SGOT(140 IU/L), SGPT (228 IU/L), ALP (162IU/L), and blood urea(47 mg/ml) values. The patient was diagnosed to have developed Dytor plus induced toxic epidermal necrolysis. Discontinued the medicine and prescribed with Dexamethasone injection, IgG Injection, Cefotaxime injection, Cloxacilline capsule, Cetirizine tablet, Hydroxypropyl methylcellulose eye drop, and candid mouth paint. The patient had a hospital stay of 25 days. Conclusions: The patient improved symptomatically. Causality was assessed as per the WHO-UMC causality scale and this case was put in the probable category. This case was uploaded via vigiflow under the pharmacovigilance programme of India having report Id 2019-30695.

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Objective: The objective of the study was to evaluate the anti-oxytocic activity of ethanolic extract of Asparagus racemosus root. Methods: Ethanolic extract of A. racemosus root was taken by Soxhlet extraction method. Wistar strain albino non-pregnant female rats of weight 200–300 g were pre-treated with estrogen and were sacrificed to take their uterus. The tissue was then mounted in an organ bath containing de Jalon’s solution. The response of the tissue to various doses of oxytocin alone and then on adding increasing doses of the alcoholic extracts of A. racemosus along with the dose of oxytocin which produces sub-maximal contraction were recorded on a smoked drum. Results: Extract in doses up to 40 mg when given along with oxytocin 0.1 unit produced graded increase in contractions in rat uterus. From 80 mg onward graded blockade of contractions occurred with complete blockade at 200 mg. On complete removal of the extract by thorough washing, it was seen that oxytocin was again able to produce contractions of the rat uterus tissue. Conclusion: The ethanolic extract of A. racemosus root had demonstrated good anti-oxytocic property.